Innovative BioRegenerative Therapies at BelleSante
Personalized Stem Cell Collection
We at BioSculpt™ by BelleSante are creating a path to “Living a Healthier, Longer Life” and our Regenerative Medicine offerings are rapidly expanding. Kristine Romine, MD, Sara Romine, DNP, FNP-C, and our Team view our personal stem cells as “precision tools” within the regenerative toolkit - offering the targeted power of stem cells with greater safety and control. Our experts painlessly and non invasively collect about 50 easily accessible hair follicles, containing progenitor Mesenchymal Stem Cells (MSCs) from the back of your scalp, preserving a rich niche of diverse, viable cells, including fibroblasts and keratinocytes. After collection, cells are tested in the ACORN lab to confirm viability and functionality.
Next your cells are cryogenically preserved at -196° Celsius which halts aging and maintains their Youthfulness, capturing them at your current Biological Age, indefinitely. These preserved cells are then available for use in:
- Cell-based skincare (see “Secretome” below) and cosmetic products
- Autologous cell therapies (e.g., skin grafts, wound repair)
- Future interventions like iPSC reprogramming (e.g., organ regeneration and disease therapies)
These preserved cells are rich in exosomes, growth factors, cytokines and other powerful molecules that can be transformed into your own personalized "Secretome" — concentrated solutions that support skin and hair rejuvenation. When integrated into your comprehensive wellness plan, these preserved cells can be used to heal your body now and become a foundation for current and emerging Regenerative Aesthetic Medicine treatments, allowing you to access and use your own, currently youngest, healthiest cells, creating a pathway to “Age Healthier.”
Your Treatment Experience at BioSculpt™ by BelleSante
Your Personalized Progenitor Stem Cell Collection experience begins with a thorough consultation with Kristine Romine, MD or Sara Romine, DNP, FNP-C to explain the process and answer all your questions. Next, our experts comfortably collect your hair follicles from the back and sides of your head, which feels similar to having your hair gently pulled. These areas are chosen specifically because the hair follicles there contain the highest concentration of viable stem cells. The extracted follicles are then transported to ACORN's state-of-the-art facility. There, your cells undergo careful analysis for viability before being separated into multiple vials and cryogenically frozen at -196° Celsius. This preservation technique maintains your cells in their current state indefinitely, meaning cells collected at age 30 remain biologically 30, even decades later. The earlier you harvest your hair follicles, the younger your cells will be for future use. When integrated into your comprehensive wellness plan, these preserved cells can be used to heal your body now and become a foundation for current and emerging Regenerative Aesthetic Medicine treatments, allowing you to access and use your own currently youngest, healthiest cells, creating a pathway to “Age Healthier.”
Personalized “Secretome” Therapy
Your preserved cells can currently be used to create your highly personalized “Secretome” serum — concentrated solutions containing your own growth factors, cytokines, exosomes and other powerful regenerative molecules. These customized formulations support:
- Enhanced skin rejuvenation when combined with microneedling
- Accelerated healing after laser treatments, including BelleSante Airbrushing and BelleSante Glow
- Improved healing times and stimulation of collagen and elastin after aesthetic treatments, including BelleSante Radiant Refresh XO, and BelleSante MicroLift XO
- Support for hair restoration therapies
- Natural collagen and elastin stimulation
Platelet-Rich Plasma (PRP) Therapy
Your blood contains powerful healing factors that can dramatically enhance your body's natural regenerative processes. PRP therapy harnesses these concentrated healing elements to stimulate cellular renewal, improve skin quality and accelerate the recovery process.
At BelleSante, our PRP treatments utilize advanced processing techniques developed over more than a decade of experience. We draw a small amount of your blood, process it to concentrate the platelets and growth factors, and then strategically reintroduce these healing elements to targeted areas. PRP applications at BelleSante include:
- Enhancing skin texture and tone improvement
- Stimulating natural hair growth and restoration
- Accelerated healing when combined with other treatments
- Improving results from microneedling and laser procedures
- Rejuvenating your skin’s overall appearance
Our unique PRP techniques ensure optimal clinical outcomes with minimal discomfort and downtime. By pairing PRP with many of our BelleSante Exclusive Treatments, we create comprehensive approaches that maximize your body's healing response.
Learn More about Platelet-Rich Plasma Therapy
Extracellular Vesicles (Exosomes), Biomimetic Peptides, Platelet-Derived Growth Factors (PDGF), and Polynucleotides
BioRegenerative Medicine is evolving rapidly, and at BelleSante, we integrate some of the most advanced biological tools to support your body’s ability to repair, restore, and regenerate from within.
Exosomes, microscopic extracellular vesicles derived from day-zero mesenchymal stem cells (MSCs), are used topically in many of our BelleSante Exclusive Treatments. These powerful cellular messengers deliver proteins, growth factors, lipids, and peptides that enhance tissue repair, accelerate healing, reduce inflammation, and promote regenerative activity throughout the skin and body.
Alongside exosomes, we incorporate biomimetic peptides — lab-designed molecules that mimic the body’s natural peptides to boost collagen, elastin, and skin firmness. These peptides help regulate cellular communication, encouraging healthier, more youthful skin over time.
We also utilize platelet-derived growth factors (PDGF), which signal the body’s repair systems to rebuild damaged tissue and stimulate cell proliferation. PDGF is especially effective in wound healing and post-procedure recovery.
Finally, polynucleotides — fragments of DNA and RNA — help to improve hydration, elasticity, and overall skin structure. They support cellular regeneration, particularly in delicate or aging skin.
These biologically active treatments work together as innovative solutions to harness the body’s natural healing processes and can stimulate fibroblasts to produce more collagen to combat the signs of aging, by enhancing the 3 Rs:
- REPAIR damage accumulated in cells and tissues over time
- RESTORE cellular programming to turn back the biological clock
- REGENERATE skin and tissue health by rebooting cellular function
Post-Procedure Healing & Results Enhancement
Our Regenerative Medicine solutions integrate with, and enhance, many of our BelleSante treatments — especially those that, as we like to say, “poke holes” in the skin to activate the body’s natural repair response. The REPAIR phase leads to firmer, healthier, more youthful-looking skin, much like how lifting heavy weights breaks down muscle fibers to rebuild them stronger during the recovery phase. When combined with procedures like microneedling or lasers, applications like your personalized “Secretome,” exosomes and other cell based therapies provide additional regenerative support, potentially improving your results and accelerating the recovery process (like taking creatine for muscle health and recovery). The integration of BioRegenerative Medicine into your personalized treatment plan also allows us to create truly personalized, optimized approaches for addressing your unique concerns.
