The BelleSante Radiant Refresh XO | BelleSante | Best Dermatologist in Phoenix

The BelleSante Radiant Refresh XO is a powerful and innovative cosmetic treatment that uses a combination of biostimulating Sculptra, microneedling and exosomes derived from day-zero stem cells to stimulate collagen and elastin production and improve the appearance of the skin. Whether you’re looking to reverse the signs of aging or simply maintain a youthful appearance, this treatment can help you achieve and maintain the refreshed and authentic younger-looking self you desire.

Restore Your Skin's Natural Radiance from Within

When you look in the mirror, does your reflection match how youthful you feel inside? As we celebrate more birthdays, our skin gradually loses its natural volume and vitality, leading to changes that can affect our confidence. While individual treatments might temporarily mask these changes, they often fall short of creating the comprehensive renewal you desire.

At BelleSante by Kristine Romine, MD, we've pioneered an innovative approach that works with your body's natural processes to restore your skin's youthful vitality. The BelleSante Radiant Refresh XO combines powerful biostimulation with microneedling and advanced regenerative medicine to enhance your natural beauty from within, revealing the refreshed, radiant version of yourself from years past.

What Is the BelleSante Radiant Refresh XO?

The BelleSante Radiant Refresh XO is a powerful and innovative cosmetic treatment protocol created by Kristine Romine, MD, that combines the use of a biostimulator (Sculptra) and microneedling with exosomes from day-zero stem cells to stimulate your own collagen production, improve volume loss and enhance the texture of your skin.

How It Works

Through decades of experience in “Partnering with Patients for a Lifetime of Healthy, Beautiful Skin™,” Dr. Romine has perfected the artful timing and combination of aesthetic treatments. Her innovative protocols maximize the benefits of each component while maintaining your comfort and minimizing downtime. Each element of the BelleSante Radiant Refresh XO is carefully curated and administered to create comprehensive results that look completely natural.

Treatment begins with the biostimulator Sculptra, a type of “re-inflator” made with poly-L-lactic acid, a synthetic material that triggers the production of our own collagen — an important protein that gives our skin structure and elasticity. As an injected biostimulator, it helps to restore very natural-looking volume over time, reducing the appearance of fine lines and wrinkles. We enhance these results with microneedling treatments that create tiny punctures in the dermis, activating the body’s healing response and further stimulating new collagen and elastin production, resulting in beautiful smoothness to the skin.

To complete your Radiant Refresh, we introduce exosomes derived from day-zero stem cells.

Exosomes are small vesicles containing powerful growth factors, proteins, lipids, and other molecules from very young cells that help repair and regenerate tissue like very young cells. When administered by an expert, such as Dr. Romine or Sara Romine, DNP, FNP-C, exosomes work together to maximize your skin’s regenerative potential for truly remarkable results.

Benefits of the BelleSante Radiant Refresh XO

Natural-looking volume restoration through your own collagen production
Enhanced skin regeneration with precisely timed application of exosomes
Gradual, progressive improvements over three to six months
Long-lasting results that can persist for up to two years when a full series of three to four sessions is completed; yearly session recommended for maintenance
Minimally invasive treatment with little to no downtime
Strategic treatment sequencing to maximize results
Personalized KRMD Advanced Medical Skin Care routine for optimal maintenance

Recovery & Results

After the Treatment

You will receive your first massage and guided on technique, in office, directly after injections. At home, you will be asked to perform “5-5-5 massages” — 5 minute massages, 5 times a day, for 5 days to maximize results of optimal collagen and elastin tissue stimulation.

After your BelleSante Radiant Refresh XO treatment, you may experience mild redness and increased sensitivity that typically subsides within 24-48 hours. You will be absolutely delighted with your newfound youthful volume for the first 48 hours and we always encourage our Radiant Refresh lovers to plan a nice event for the first two days. Two days after the procedure, you will note the original volume is back to your baseline as the sterile water the biostimulator is mixed in has fully resorbed into your body. Don’t worry… the desired volume is on its way and will be enhanced by your adherence to the “5-5-5 massages.” Your results develop gradually as the treatments work with your body's natural processes. While you may notice initial improvements in skin firmness and texture within the first few weeks, the most significant changes emerge over the following months as new collagen and elastin form.

Dr. Romine and Sara Romine, DNP, FNP-C, provide comprehensive guidance throughout your treatment journey, including detailed instructions for maximizing your results with your prescribed KRMD Advanced Medical Skin Care routine. Their expertise ensures optimal outcomes while maintaining your comfort and safety at every step.

Ideal Candidates for the Bellesante Radiant Refresh XO

The BelleSante Radiant Refresh XO offers a sophisticated solution for those seeking the most natural-looking rejuvenation. This treatment excels at addressing the early signs of aging while promoting long-term skin health through enhanced collagen production.

You may be an ideal candidate for this BelleSante Exclusive Treatment if you:

Want to restore your skin's natural radiance and vitality
Notice early signs of volume loss or skin laxity
Prefer gradual, natural-looking improvements
Seek long-term results through collagen stimulation
Value treatments that work with your body's natural processes

During your consultation, Dr. Romine and Sara Romine, DNP, FNP-C, will evaluate your skin's current condition and discuss how the BelleSante Radiant Refresh XO can be customized to address your specific concerns while supporting your long-term aesthetic goals.

What Our Clients Are Saying

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“Dr. Romine, Sara, and the team at BelleSante are absolutely wonderful. I’ve been seeing Dr. Romine and Sara for years now and trust them wholeheartedly to recommend treatments in line with my desire to age gracefully…From the expertise of the team to the welcoming atmosphere, every detail at BelleSante is carefully curated to provide an exceptional experience. I would absolutely recommend them to anyone seeking top-quality treatments delivered by the best in the field.”

Krista D.

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“Dr. Romine has wonderful bedside manners. She has narrowed down and pin pointed exactly what aging gracefully should look like. BelleSante is everything you need and more.”

Heidi R.

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"I recently had the pleasure of visiting Dr. Romine and the experience was nothing short of fantastic! From the moment I walked into her office, I was greeted with warmth and professionalism. The staff is excellent which is crucial when you trust someone with your skin's appearance and health.

Dr. Romine stands out as one of the most knowledgeable and skilled cosmetic derms I've encountered. Her expertise in anti-aging and skin rejuvenation is unparalleled. She's an amazing listener who always delivers perfection. Highly recommend!"

Kara F.

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“Dr. Romine is by far the best dermatologist I have ever seen. I have been going to her for many years. She is very caring, meticulous, and up on all of the latest in her field! Her office is very inviting and her staff is wonderful. Would highly recommend her! She is amazing! 😊”

Beth Ann A.

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"Always love my treatments with Dr. Romine. She is kind, professional, and most of all a true artist."

Kira M.

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“Just had The most amazing visit with Dr. Romine!!! She is so knowledgeable and caring. What I love most is her passion for health and the full picture! Exercise, eating right, hormones and so much more. She’s interested in the whole body. Once you find someone this good … you’re a client for life!!”

Tonya R.

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“There is no one better or more qualified in the business. All treatments and advice offered are cutting-edge, science-based, and heavily researched. Furthermore, Dr. Romine is an award winning Mohs surgeon and Dermatologist pursuing her passion in cosmetics and wellness - you could not wish for more than Dr. Romine and her team!”

Christine G.

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“Every aspect of my visit was above and beyond…Dr. Romine was just amazing. She answered all my questions and went through the procedure of Ellacor showing me pictures of how it works and before and after pictures of other patients that have had it done. She is the best example of how well you heal and look after having done it herself…I would highly recommend BelleSante.”

Stacy D.

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"Integrative medicine, health, and beauty combined with Dr. Romine at the helm. It doesn’t get any better than this. The practice is welcoming and the staff are friendly."

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Mima S.

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“Dr. Romine is absolutely one of the best in the business. The time and care she takes with her patients leads to the most natural looking results. If your goal is to be the best, youngest version of YOU, she will help you get there through a series of at-home care and in-office treatments. And to top it off, her staff couldn’t be more professional with the utmost warmth and compassion.”

Cheryl N.

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“Very friendly staff, and Dr. Romine's interest in maximizing one's HealthSpan is inspiring. I always learn something new from her, as I think she is constantly learning new things herself. Great results, too--subtle and natural.”

Judy S.

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“I’m 69 years old. I purchased a package of six Emsella Chair treatments before taking a cruise vacation. I was very pleased to have experienced such a remarkable improvement. I was able to do all ports of call without worrying about finding a toilet! It was so freeing! Thank you Dr Romine.”

Terri M.

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"Simply the BEST in phoenix! Dr Romine & Sara can truly be trusted with your skin health & more. They are Angels and the staff is so professional and genuine."

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DJ P.

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The BelleSante Difference

At BelleSante by Kristine Romine, MD, we understand that true transformation goes beyond addressing a line here or a wrinkle there. As pioneers in Aesthetic medicine, we take a more comprehensive approach to beauty and wellness that considers the complete picture — how you look, feel and live.

Achieving your goals isn’t just about using the latest tools and technology. It’s about how they’re artfully combined to bring out the best in your skin. Like a skilled architect, Dr. Romine and Sara Romine, DNP, FNP-C understand that rejuvenating one area sometimes requires strengthening the foundation around it first. This allows us to achieve results that not only enhance your authentic appearance but inspire overall beauty and wellness, as well as confidence.

We've seen firsthand how looking and feeling your best can transform your mindset and improve all aspects of your life. Our patients often find that once they begin their aesthetic journey with our professionals, they feel empowered to pursue goals they once thought were out of reach. That is the true BelleSante difference: providing you with the knowledge and support you need to live your most vibrant life.

At BelleSante, we “Partner with our patients for a Lifetime of Beautiful Health.”

The BelleSante Difference

Many providers take an overly simplistic approach to neuromodulator treatments, focusing on individual lines without considering the whole picture. This can lead to results that are unnatural or unflattering for a patient’s specific features.

At BelleSante by Kristine Romine, MD, we consider how each facial feature and muscle group works together to create your unique expressions. Dr. Romine and Sara Romine, DNP, FNP-C, carefully observe your natural facial movements and create an injection map specific to your anatomy. We often integrate neuromodulators into our Exclusive Treatments, like The BelleSante Skin Gym, to deliver comprehensive rejuvenation that maximizes the health and beauty of your skin.

Balance and proportion guide our injection philosophy. Instead of over-treating certain areas, we distribute neuromodulators thoughtfully to create symmetry and harmony throughout your face, neck and even beyond. Dr. Romine’s signature micro-droplet technique delivers exceptionally natural results, so you'll leave BelleSante looking like you, only better.

Connect With Us

At BelleSante by Kristine Romine, MD, we believe in “Partnering with Patients for a Lifetime of Healthy, Beautiful Skin™.” Through our deep understanding of facial architecture and commitment to natural beauty, we help you achieve the refined, radiant results you deserve.

Ready to begin your transformation? Let's create your personalized BelleSante Radiant Refresh XO treatment plan together.

Connect With Us

At BelleSante by Kristine Romine, MD, we believe that every aesthetic journey should be as unique as you are. Through our artistic approach and deep understanding of facial anatomy, we help you achieve the refined, natural-looking results you deserve.

Call: 480-878-0087

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